Clinical Significance Of Serum Anti-oxidized Low Density Lipoprotein Antibodies In Hyperuricemia

Objective To investigate the serum anti-ox-LDL-Ab level in patients with hyperuricmia and association with dislipidemia and with or without hypertension, and to analyse its relationship with serum uric acid (SUA),blood lipid,blood pressure and its clinical significance.Methods In the study, 138 patients with hyperuricemia were enrolled. They were further divided into simple hyperuricemia patients (UA-1 group, 59 subjects), hyperuricemia and hyperlipidemia patients (UA-2 group, 36 subjects), hyperuricemia association with hyperlipidemia and hypertension patients (UA-3 group, 43 subjects). And 42 normal persons were enrolled as control group (CON group). The serum anti-ox-LDL-Ab level was measured using competitive Enzyme Immunoassay kit. At the same time, their blood pressure, height, weight, blood lipid, plasma glucose etc. were measured and the weight index were calculated. All the data and number measured were showed with mean ±standard deviation. Analysis of variance was used to compare between several groups. Bonferroni means was used between groups. Single factor liner correlated analysis was made between the experiment indexes and multiple stepwise regression analysis was made in multivariables for their relativity.Results Compared with the hyperuricemia group, The serum anti-ox-LDL-Ab level was obviously lower in the CON group (32.81 + 15.29 vs 45.27+29.03, P<0.05). Compared with the CON group, the descending of the serum anti-ox-LDL-Ab level in the UA-1 and UA-2 group has no statistics sense, but the reduce of the serum anti-ox-LDL-Ab level in the UA-3 group has great statistics sense. Multiple stepwise regression analysis showed that the antibody level was negatively correlated with blood uric acid and LDL-C, while positively correlated with HDL-C. The standardization partial regression coefficient was -0.1(P=0.016), -0.229(P=0.003) and 0.265(P=0.001) separately.Conclusions 1.The serum uric acid was negatively correlated with anti-ox-LDL-Ab, which was an independent dangerous factor that affected the anti-ox-LDL-Ab level. 2. Anti-ox-LDL-Ab was positively correlated with HDL-C and negatively correlatd with LDL-C, which supported that...