Apoptosis And Regeneration Of Olfactory Receptor Neurons In Patients Suffering From Dysosmia Caused By Chronic Sinusitis

Objective: One of the most common causes is chronic sinusitis. Olfactory receptor neurons (ORNs) not only can regenerate,but also they are true bipolar neurons directly exposed to the external environment. As an adaptive mechanism, the link between ORNs apoptosis and regeneration maintains a balance. If this balance is disturbed, the ORNs apoptotic capacity overwhelms the regenerative capacity, which will result in dysosmia. Is the mechanism of a net loss of ORNs in patients suffering from dysosmia caused by chronic sinusitis apoptosis or necrosis? What is the link between loss and regeneration of ORNs in chronic inflammatory? These questions have not reported in our country. To study apoptosis and regeneration of ORNs in patients suffering from dysosmia caused by chronic sinusitis, and the correlated genes, in order to elucidate the possible mechanism of dysosmia caused by chronic sinusitis. It provides a theoretical base for clinical general treatment with drugs and Functional Endoscopic Sinus Surgery (FESS).Methods: 1 Choosing cases, grouping and obtaining specimens Forty-six patients ranging in age from 20 to 56 years underwent FESS in...