Association Of STAT6,STAT4,IFN-γ和IL-4 Gene Polymorphisms And Asthma

BackgroundIn recent years, the number of patients suffering from allergic asthma has increased , and allergic diseases including asthma have become a social problem affecting medical costs and quality of life. Allergic asthma is a complex disorder characterized by airway inflammation,bronchial hyperresponsiveness and reversible airway obstruction. Elevated numbers of activated Th2 cells, mast cells and eosinophils in the bronchial mucosa cause certain features of asthma, including increased serum IgE levels in allergic asthma. The available data suggest that there are many potential susceptible genes for allergic asthma, including genes for cytokines, receptors, transcription factors,immune recognition.Asthma may be based on an inflammatory mechanism involving T-helper type 2 cytokines, such as IL-4 and IL-13, through their receptors.Upon release of IL-4 or IL-13, binding of the cytokine to it receptor at the cell surface induces receptor dimerization and activation of the Janus tyrosine kinase 3 and the transcription factor STAT6 . Tyrosine phosphorylation of signal transducer and activator of transcription 6 mediates homodimerization, triggering movement to the nucleus, and leading to its specific binding to promoter sequences in the DNA . STAT6 DNA-binding sites have been identified in the promoter regions of several IL-4-inducible genes. This can result intransactivation of the target genes, which have central roles in IgE synthesis and the development of bronchial hyperresponsiveness.The signal transducer and activator of transcription 4 on chromosome 2q32.2–q32.3 is known to be essential for mediating responses to interleukin 12 in lymphocytes and regulating the differentiation of T helper cells.IFN-γbelongs to a cytokine class that affects the immune function, in fact it plays a major role in the induction of the immune-mediated inflammatory response.ObjectiveTo study the 2964G/A variant of the Signal transducer and activator of transcription 6...