QSJZY Influence CD40/CD40L Expression In Peripheral Blood And Abdominalis Aorta Of SD Rat

Atherosclerosis is a harmful severity and frequently encountered disease to human healthy ,Its disease incidence is increasing year by year, people more and more think highly of etiopathogenesis as well as clinical therapy.Atherosclerotic occurrence and development is a arterial disease of chronic inflammation, immunoreactive course. Leucocytic differentiation antigen 40 sign-al access participates in regulation of inflammatory reaction accommodation of major cell component (vascular endothelial cell,vascular smooth muscle cell and macrophage) , it is playing critical role in AS process, participates ather-osclerotic occurrence and development ,reside in atherosclerotic plaque cell thro-ugh CD40-CD40L interaction, induce activate by itself , express and secrete profit to happen immune response,inflammatory reaction,hemagglutination t-hrombogenic proteo-cytokine. Such as activating the crucial cell component of atherosclerotic plaque , create adhesion molecule,inflammatory factor,matrixm-etalloproteinase and so on . Induce instability and disruption of plaque. Induce to aggravate pathological changes of atherosclerotic plaque in the ultimate.Hypercholesteremia is one of capital risk factor of atherosclerosis, have cl-ose relation with inflammatory reaction and hypercoagulabale state in artherosc-lerosis procedur , CD40L regulate the two pathways . Blocking the interaction of CD40 and CD40L,not only inhibit artherosclerosis occurrence and developm-ent ,but also change plaque bionomics and structure, increase plaque Stability .The experiment utilize self-made traditional Chinese medicine QSJZY...