Injuries Of Homocysteine To Cultural Vascular Endothelial Cell And The Protection Of Flunarizine Hydrochloride

Ischemic cerebralvascular disease(ICVD) is the major cause of disability in developed countries. It was believed that age, hyperlipidemia, hypertension, diabetes and smoking are common risk factors for ICVD. Inaddition, overwhelming clinical and epidemiological studies have identified homocysteine(Hcy)as a significant and independent risk factor for ICVD. The oxidation of homocysteine promotes the oxidation of low-density lipoprotein cholesterol, which causes injury to vascular endothelial cells and leads to endothelial dysfunction. Homocysteine also promotes vascular smooth muscle cell growth, and increases I platelet thrombox and A₂ production, platelet aggregation and factor V activity. Moderate and intermediate hyperhomoxysteinemia is believed to be associated with BI. Although folic acid, vitamin B₁₂ and B₆ Can lower plasma Hcy levels, the long-term effects on ICVD risk are still unknown and judgments about therapeutic benefits await the findings of ongoing clinical trials. There are some studies indicate that lowering homocysteine did not prevent recurrent stroke induced by homocysteine. Now,...