Changes Of CD10, CK7, CK20 And CDX2 Expression In Gastric Cardia Adenocarcinoma And Intestinal Metaplasia Adjacent To Gastric Cardia Adenocarcinoma

BackgroundLinzhou and nearby counties in Henan Province are the high incidence area for esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA). In the last two decades, adenocarcinoma at gastro-esophageal junction (GEJ) has increased dramatically in western countries and the sequence from reflux esophagitis-Barrett's esophagus (intestinal metaplasia) -dysplasia-adenocarcinoma has been hypothesized as the histogenesis model for the adenocarcinoma originated at GEJ in western countries. Comparing with western country, distinctly difference is 95% esophageal cancer is SCC in Linzhou. The incidences of esophageal adenocarcinoma, reflux esophagitis and especially Barrett's esophagus are much lower in Chinese population. And most of GCA occurs below the Z-line in China. The prevalence of IM adjacent to GCA and its relation with GCA has not been well characterized. Our research group found that intestinal metaplasia (IM) might be a...