The Effect Of Remifentanil On Stress Response In Different Anesthesia Techniques During Thoracic Surgery

Background and ObjectiveRemifentanil is a new synthetic opium μ-receptor agonist with ultra-short-acting. There is no drug accumulation and the context-sensitive half-time remains3-4minutes, which is independent of the duration of the infusion, and there is no clinically relevant difference in the pharmacokinetic profile in surgical patients with end-stage hepatic or renal disease. These characteristics make it a hot study in clinical anesthesia.Thoracic surgery is a routine treatment for the patients who have got chest tumor or other diseases. For one thing, when thoracic cavity is opened up, the negative pressure of chest cavity will be changed into positive, it will lead to respiratory physiology disorder following lung wither, breathing abnormal, mediastinum shaking. For another, the positive pressure reduce returned blood volume, which comes back from peripheral vein. So it is possible that decreased blood volume in heart may induce myocardial ischemia following a hypotension. Surgical irritation and pull can cause a bad cardiac arrhythmias even cardiac arrest .So it is always strict for anesthesia techniques and administration. Traditional anesthesiological concept holds that there must be analgesia and balance of physiology during surgery, the alternative anesthetic technique for thoracic surgery is always general anesthesia with tracheal intubations to be sure that airway is relax, muscle can be relaxed enough, stable homodynamic can be maintained. Modern anesthesiological concept requires that in addition to relieveing patients' pains, maintaining their physiology stable,...