| Objective: To study the effects of recombinant human brain natriuretic peptide (rhBNP) on the cardiac hemodynamics and heart function in the rabbits with heart failure.Methods: Congestive heart failure in rabbits was induced by damaging aortic valve of rabbits with ductus. Cardiovascular functional indicators were determined using echocardiography after five weeks. Rabbits of heart failure were classified into three groups randomly, and were given rhBNP, nitroprusside sodium and placebo (glucose) to treat. Cardiovascular functional indicators of rabbits were detected with echocardiography before and after therapy. The same three series of drugs were given after one week, and the change of hemodynamic parameter was observed before and after therapy. Heart, lung and liver of rabbits were dislodged for histopathologic examination after they were accepted twice dosages.Results: they were discovered by using echocardiography after five weeks that LVEF had decrease but LVEDV, LVESV and LAD had scale-up. LVEDP had step up after six weeks.LVEF of the rabbits with heart failure remarkably increased after treated by rhBNP. (LVEF: 0.63±0.06 vs 0.70±0.07) , HR was descended (HR: 239.6±41.7bpm vs 218.9±31.4bpm), LVESV and LAD was significantly reduced (LVESV: 2.1±0.7ml vs 1.2±0.9ml; LAD: 11.0±1.9mm vs 10.1±1.8mm),the change of CO and LVESV wasn't obvious. LVEF, LVESV and LAD weren't conspicuous variation in the nitroprusside sodium and placebo groups.The detecting of hemodynamic parameter indicated that remarkable changes appeared in the rhBNP group. sixty minutes after rhBNP infused intravenously, LVEDP,DBP and MAP had decreased(P<0.05); and LVEDP,DBP and MAP were still... |
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