The Preliminary Study Of Subarachnoid Hemorrhage In Rabbits With MDCT Perfusion And Multimodality MR Imaging

Background and purpose: Subarachnoid hemorrhage (SAH) is a common and serious neurologic emergent condition. Vasospasm has long been considered the most dreaded acute complication after SAH. Despite the progress in understanding its pathophysiology and the significant improvement in clinical outcome following treatment of intracranial aneurysm rupture with nimodipine and triple-H therapy, the course of cerebral vasospasm and delayed ischemic neurological deficits (DIND) remains unchanged. The aim of the present study is to explore the alterations of cerebral microcirculation and diffusion in rabbit SAH and their relationship by means of the up-to-date 64 detector CT perfusion (CTP) and MR diffusion weighted imaging, and to provide the theoretical basis for therapy.Methods: Rabbit SAH model was produced by a two-hemorrhage method (blood injection into the cisterna magna). Fifty-eight adult New-Zealand rabbits of either sex, weighing 1500-2500g were used for this study. All animals were randomly assigned into 3 groups: group A (normal control, n=10), group B (SAH, n=24), group C (Sham-operated control, n=24). At the 1st stage of this study, According to observation time and imaging modality, group B and C were randomly subdivided into 6 groups: CTP 5, 15, 30, 60 and 90 minutes group and ADC continuious observation group, 4 animals per group. CT perfusion was performed at 5 min, 15 min, 30 min, 60 min and 90 min after the 1^st and 2^nd operation; MR diffusion weighted imaging was performed in...