The Clinical Investigation About The Relationship Between Cys C,Hcy,TNF-a With CHD Or HF

Objective In this study, we observed the changes of Cystatin C(Cys C) , homocysteine(Hcy) and tumor necrosis factor-a(TNF-a) concentrations in coronary heart disease(CHD) or heart failure(HF). Meanwhile, to analyze the relationship between Cys C, Hcy, TNF-a and CHD or HE We also measured systolic(Sm), early(Em) and late diastolic(Am) velocities of mitral annular(MA) and to evaluate the clinical value of doppler tissue imaging (DTI) in quantitative detection of global left ventricular systolic and diastolic function.Methods (l)The first section: The clinical investigation of Cys C,Hcy and TNF- α in Patients with CHD The subjects were recruited from among consecutive cases admitted to the First Affiliated Hospital of Anhui Medical University from february 2005 to December 2005.They were divided into three groups according to coronary angiographic results and clinical diagnose: 60 control subjects, 50 patients with stable angina pectoris (SAP) and 52 patients with acute coronary syndrome (ACS). Serum Cys C,Hcy, TNF-a concentrations were measured by enzyme linked immunosorbent assay (ELISA) .Meanwhile, we used an HP Sonos 5500 ultrasound system equipped with a multifrequency transducer and the DTI program to measure left ventricular ejection fraction(LVEF) and Sm,Em,Am of MA at the posterior wall and mid interventricular septum from long axis view and the apical four- chamber views, respectively. We also analyzed the relationship between serum levels of Cys C,Hcy,TNF-a and coronary arteriography(CAG) results.All data analysis was performed with the Statistical Package for Social Sciences (SPSS 12.0) software. (2)The second section: The clinical investigation of CysC,Hcy and TNF-α in...