Effect Between Apolipoproteins A5 And The Metabolism Of Serum And Relative Disease

BackgroundAtherosclerosis and coronary atherosclerotic heart disease (CHD) are sort ofdisease threatening the health of human beings, and hyperlipidemia is a major independent risk factor of CHD. Studies of recent years make it clear that cholesterol (CH) is correlated positively with the occurrence and development of CHD, but the relationship between triglyceride(TG) and CHD is not confirm like this. Most studies suggested, hypertriglyceridemia and low level of high-density lipoprotein cholesterol(HDL-C) can increase the morbidity of CHD. Hypertriglyceridemia can cause the decrease of HDL-C and the increase of small dense LDL, they have intimate relationship on metabolism, we call them atherogenic lipoprotein phenotype ( ALP). They are the status of lipid disturbance which can cause atherosclerosis easily. Diabetes mellitus (DM), have equal danger to CHD, the most common dyslipidemia is hypertriglyceridemia, which is a independent risk factor of CHD for DM patients. If we lower the levels of serum triglyceride in person who have CHD or DM or family history of CHD early onset, we can reduce the risk of occur CHD.Recent years, people find out that lipoprotein has severely effect on atherosclerosis than cholesterol through the study about metabolism of lipoprotein. Apolipoprotein is the protein part of lipoprotein. It play an important role in combine and transport lipid and stabilize structure of lipoprotein, also it regulate activity of key enzyme in lipoprotein metabolism. Apolipoprotein attend all process of lipid metabolism in human, so people take most attention about it on discover the mechanism of cardiocerebral- vascular disease. Apolipoprotein A5 (APOA5) is a...