Experimental Study Of Peroxisome Proliferater-activated Receptor For The Cardiac Extracellular Matrix Of InFlammatory Remodeling

1. BackgroundHeart failure is the final phase of many kinds of heart disease. While the remodeling is the important of the process of heart failure.Studying the physiopathological basis of myocardial remodeling and trying the best to find the methods to affect it Have the vital significance for the prevention and cure heart and Blood vessel disease. As the study shows, myocardial remodeling Contains the myocardial cell and extracellular matrix (ECM) remodeling, while the ECM remodeling represents the change of the Content and the structure of the collagen. Peroxisome Proliferater-activated Receptor(PPAR) is a nuclear transcribe factor which is activated by the gamete ,belonging to the nuclear Acceptors family II and which take the pivotal role in regulating The oxidation of the fatty acid. Recently, investigation shows that The PPAR have the role of resisting the remodeling, but the mechanism Hasn't been elucidated. In this experience, we cultivate the cardiac Cfs of the big rats, give them the stimulation of Ang II, then the Disturb with PPAR-γ,finally we observe the effect the PPAR-γ makes On the CFs in the big rats'hearts, as to discuss the possible mechanism of the PPAR-γ in resisting the remodeling.2. GoalObserve the roles of PPAR-γ in resisting the remodeling of...