Effects Of Salvia Milltiorrhiza Combined With Methylprednisolone On INOS Positive Neurons And The Recovery Of Locomotion Of The Hind Limbs In The Rats Of Spinal Cord Injury

Background: Acute spinal cord injury (SCI) often results in dysfunction of voluntary motor and sensory below the site of injury. The effects of clinic treatment has been dissatisfactory after acute spinal cord injury . This refractory disease often makes some patients lose the ability of labor and life. The dysfunction following acute spinal cord injury is contribute to both direct mechanical injury and secondary pathophysiological mechanisms induced by initial trauma. Extensive evidence indicates that there are reciprocity and wide disturbance of neurobiochemistry and microcirculatory. Especially, the disturbance of microcirculatory plays important role in the secondary spinal cord injury. More attention was paid to the relation between inducible nitric oxide synthase and neurological deficits. Study showed that excessive nitric oxide synthase induce neurological deficits. Methylprednisolone can keep from second spinal cord injury in several aspects. In clinic, the high dose of methylprednisolone has been used as one of the principle in the treatment of spinal cord injury for several years. The accurate mechanism is not clear. The experiments showed that salvia milltiorrhiza can promote function recovery of spinal cord injury in t rats. There were clinic reports of treatment with Salvia Milltiorrhiza in spinal cord injury. But Salvia Milltiorrhiza enhances the expression of NOS positive neurons while methylprednisolone restrains the expression. Application of Methylprednisolone combined with Salvia Milltiorrhiza can promote recovery of bilateral hind limbs of the rats after spinal cord injury.Objective: To investigate the effect of Salvia Milltiorrhiza (SM) combined with Methylprednisolne (MP) on nitric oxide synthase (NOS) positive neurons and...