Study The Expression Of Cyclooxygenase-2 Protein In Human Hepatocellular Carcinoma And Correlation With Multidrug Resistance

Cyclooxygenase (COX) ,also called prostaglandin peroxidate synthetase,is rate-limiting enzyme which catalyses arachidonic acid synthesizing endogenous prostaglandin, including three types of isomeride. Cyclooxygenase-2(COX-2) is the induction type of COX,Taking part in many inflammation progress. Recent studeis shows that cox-2 overexpression in many tumour cells even plays an importantly biological part in the process of the tumor's birth,growth,invasion and metastasis,Therefore,COX-2 become the hot spot to study in domestic and exterior.To synteresis and treat some tumors especially gastroenteric tumor had gained rudiment effect by specific inhibitor of COX-2 .P-glycoprotein(P-gp) is the products of multidrug resistance-1(MDR1),and P-gp/ MDR1 was received by all as one of the major mechanisms to mediate the tumor multidrug resistance,Also the multidrug resistance mechanisms was the most generally and deeply studied and was corroborative in clinical practice.Recently studied shows that cox-2 take part in the multidrug resistance...