Effects Of Lidocaine Pretreatment Against The Inflammatory Response Of Lung Injury In Rabbits

It's well known that gram-negative bacterial sepsis is the most common clinical setting in which diffuse lung injury resulting in adult respiratory distress syndrome develops. Intravenous infusion of Escbericbia coli endotoxin causes acute lung injury and alterations in lung physiologic processes similar to those in humans. Numerous factors have been shown to be involved in the initiation and perpetuation of endotoxin-induced acute lung injury. Inflammatory response is thought to play an important role in the pathogenesis of the lung injury by activating inflammatory cells and releasing inflammatory mediators.Lidocaine has been shown to have various inhibitory effects on inflammatory response. Lidocaine has been reported in plasma concentrations of 0.5-4.5ug/ml to inhibit neutrophil chemotaxis and superoxide anion release, stabilize cell membranes and interfere with binding of endotoxin to membranes. Lidocaine has been reported to attenuates acute lung injury induced by various causes, such as endotoxin, tracheal HCL installation, long-term exposure to high oxygen concentrations, etc. However, the dose-respones of lidocaine and the precise mechanism are not as yet fully understood.Our goal were to evaluate the effect on inflammatory response and dose-response relationship of lidocaine pretreatment in Endotoxin-induced acute lung injury rabbit model.Materials and Methods:...