Investigation Of The Expression Of CD154 And Cell Immunity In The Patients With Chronic Idiopathic Thrombocytopenic Purpura

Objectives: To determine the influence of CD40/CD154 interaction and cell immunity on the pathogenesis of chronic idiopathic thrombocytopenic purpura (CITP), we investigated the cell immunity and the expression of CD40 ligand(CD154) in the patients with CITP.Methods: The expressions of costimulatory molecules(CD154) and CD25 on the peripheral blood lymphocytes were measured by flow cytometry in 20 patients with CITP before and after treatment and in 10 healthy volunteers. The platelet counts were measured simultaneously.Results: The expressions of CD3+CD25+ were increased in CITP patients compared with that in healthy volunteers (P<0.05). Among the CITP patients with remission, the expressions of CD3+CD25+ were significantly lower after treatment than before. Meanwhile, the expressions of CD3+CD25+ were decreased in CITP patients with remission compared with those without remission(P<0.05). In addition, we observed significantly increased expressions of costimulatory molecule CD154 in CITP patients compared with that in healthy volunteers (p<0.05). Among the CITP patients with remission, the expression of CD4+CD154+ were markedly decreased after treatment compared with before treatment. At the same time, the expression of CD4+CD154+ were much lower in CITP patients with remission than...