The Significance Of Skp2 And P21 In The Process Of Breast Hyperplasia Cancerating

Objective: Many studies discovered that Ras oncogene (whose expression product is p21 protein) plays an important role in the carcinogenesis and the development of breast cancer. Skp2 gene (whose expression product is Skp2 protein) is also protooncogene, which often overexpresses in breast cancer and is related with differential degree of breast cancer. But the significance of Skp2 in the process of the hyperplasia cancerating is not definite. In this study, we used immunohistochemistry to detect the expression of Skp2 and p21 in the normal breast tissue, adenosis of breast, breast atypical hyperplasia, breast hyperplasia cancerization and breast cancer in order to find out if there is some correlation between these two proteins and if they cooperate to induce carcinogenesis. We also hoped to find out if they are danger factors for breast hyperplasia to transform maligantly and if they could be regarded as two effective diagnostic indictors for pristine breast cancer.Methods: 12 cases of breast cancer without lymphnode and distant metastasis, 19 cases of breast hyperplasia cancerization, 35 cases of breast atypical hyperplasia, 25 cases of adenosis of breast and 25 cases of normal breast tissue were exployed to...