Expression Of Nephrin And WT1 In Renal Cortexof Diabetic Rats And Effects Of Benazepril

Objectivcs:Proteinuria is one of the most common clinical appearance of diabetic nephropathy, which has been believed to play an important role in kidney damage. It is very important to clarify the pathogenesis for seeking the methods to prevent and treat proteinuria. The occurrence of proteinuria is associated with the glomerular filtration barrier, which is composed by endothelial cells, glomerular basement membrane and slit diagragm. Many of the studies focused on the role of the glomerular basement membrane component with particular regard to glomerular anionic sites. However, the central role of the podocyte slit diagragm in maintaining the size-selected barrier has been outlined by recent studies on different slit diagragm-associated proteins, such as nephrin, podocin, CD2-associated protein. Nephrin is the first slit diagragm-associated protein which has been discovered. Studies have recently shown that any reduced or altered expression in nephrin will cause the damage of the glomerular filtration barrier and ptoteinuria. Wilms'tumor 1(WT1) , a kind of cancerocidal gene , can control the expression of nephrin. It is very important in keeping the function of podocyte. TGF-β₁ is a important profibrogenic cytokine in the pathogenesis of diabetic...