| Objective: To investigate the mechanism of the imbalance between oxidation and anti-oxidation on the occurrence and progression of pulmonary tuberculosis and observe the therapeutic effect of antioxidant in the patients with pulmonary tuberculosis. Methods: The superoxide dismutase (SOD), glutathione peroxidase (GPX) and malonaldehyde (MDA) were detected in the sera of 20 healthy controls and 120 patients with pulmonary tuberculosis. At the same time, the blood-gas was analyzed in the 120 patients with pulmonary tuberculosis. The changes of SOD, GPX and MDA in 20 patients with pulmonary tuberculosis were observed before and after they had been given N-acetylcysteine (NAC) and anti-tuberculosis treatment for three weeks. Results: 1. Compared with the healthy controls, the level of SOD, GPX decreased and MDA increased in pulmonary tuberculosis group(p<0.01). 2. The mechanisms of the imbalance between oxidation and anti-oxidation in the patients with pulmonary tuberculosis are shown as follows. (1) Compared with the healthy controls, the levels of SOD, GPX decreased and MDA increased in the three groups with the lesion in one lung field, two and three or more than three lung fields (p<0.01). However, no difference of the levels of SOD, GPX and MDA were observed among three groups(p>0.05). (2) Compared with the healthy controls, the levels of SOD and GPX decreased and MDA increased in the patients with infiltrative or mixed lesion (p<0.01). In addition, the levels of SOD,GPX in the group with mixed lesions were lower than the group with infiltrative lesion(p< 0.01or p<0.05), but no difference was observed between the two groups as MDA was concerned(p>0.05). (3) Compared with the healthy controls, the levels of SOD,GPX decreased and MDA increased in the groups without complications and complicated with emphysema or cor pulmonale. However, no difference of the levels of SOD, GPX and MDA among the three groups were observed(p>0.05). (4)... |
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