Functional MR Study Of Intracranial Lesions In Parietal-frontal Area

Brain tumor and intracranial occupied lesions often damage the brain tissue. The impairments include pressure and infiltration in cortex and white matter .Some clinical symptoms such as headache,muscle weakness and LOM(limitation of movement )were caused by the intracranial occupied lesions. FMRI can exhibit the activation of motor cortex straight and has potential as a noninvasive tool to direct the neurosurgery .ObjectiveTo study the impact of the motor function using fMRI and DTI produce and analyze its cortex activation curves and pictures of the patients with intracranial occupying lesions situated in motor area.Materials and methodsTwenty patients had lesions involving the frontal and/ or parietal lobes in the cerebral hemispheres ,and the lesions included fifteen tumors,4 infections and 1 vascular malformation. Twenty volunteers were set up as the control group .All the participants were asked to perform repetitive finger-thumb opposition movement in the same period of active and rest duration. .The patients and volunteers had been examined by the same MRI sequence protocol. All the scanning raw data were dealt with FADA software,AFNI software and DTI-Studio software. The fMRI BOLD signals were statistical analyzed with Spss 10.0 .Results1. The motor cortex activation involved the brain tumor or occupied lesions displayed as decreased functional signal or migrated motor cortex .The contralateral M1 or SMA was weaker(thirteen patients)or stronger ( two patients) or the same as that of the normal subjects when performed repetitive finger-thumb opposition movement. Compared with mean of the BOLD signals of two groups ,there was a significant difference between patients and volunteers group (t=-3.538,p=0.001) .BOLD signals within the affected M1...