Toll-like Receptor 2 And Toll-like Receptor 4 Inducing The Rising Level Of Th1 Which May Be Significant In The Pathogenesis Of Acute Coronary Syndrome

OBJECTIVES: The study seeks to evaluate the relationship between immunity and the pathogenesis of acute coronary syndrome (ACS), toll-like receptor 2 ( TLR2)and toll-like receptor 4( TLR4) inducing the rising level of Th1, which may be significant in the pathogenesis of ACS.METHODS: 58 patients (mean age 63 years,ranged 40 to 85) are categorized into 4 groups, 21 with acute myocardial infarction(AMI), 12 with unstable angina(UA),12 with stable angina(SA) and 13 with chest pain syndrome(CPS). All the patients are testified by coronary angiography. ELISA is used to measure the level of high sensitive C reactive protein (hsCRP). Mononuclear cells expressing TLR2 and TLR4, CD4+CD28-, CD4+CD28+ are measured in the peripheral blood using flow cytometric analysis.RESULTS: The level of hsCRP in the AMI group and UA group is obviously higher than that of the SA and CPS group (P <0.05). The level of mononuclear cells expressing TLR2 and TLR4 in the peripheral blood in the AMI and UA group obviously higher than that of the SA and CPS group(P <0.05). It is obvious that the level of Th1 in the AMI and UA is higher than that of the SA and CPS group(P <0.01) while the level of Th2 shows no big difference(P >0.05). In the AMI and UA group, the level of CD4+CD28- is much higher than that of the SA and CPS group(P <0.05). The level of mononuclear cells expressing TLR2 and TLR4 is positively correlated with that of Th1( r=0.420, P <0.01;r=0.483, P <0.01).CONCLUSIONS: The level of hsCRP in the AMI group and UA group is obviously higher than that of the SA and CPS group, suggesting patients with ACS have inflammatory reaction, thus probably relating to the pathogenesis of ACS. The level of mononuclear cells of TLR2 and TLR4 in the peripheral blood in the AMI and UA group...