Alterations Of Toll Like Receptor 4 And CD14 Expression On Peripheral Blood Monocytes During The Early Stage Of Human Acute Pancreatitis

[Background] It's generally believed that acute pancreatitis(AP) is a clinical entity which is characterized by the activation of pancreatic enzymes in pancreatic acinar cells and autodigestion of pancreas. This noninfectious destruction of pancreatic parenchyma quickly induces an inflammatory reaction at the site of injury which leads to systemic inflammatory reaction syndrome(SIRS), multi-organ dysfunction syndrome(MODS) and even death. Although majority are mild with a propensity of auto limitedness,25 percent of AP will develop into severe form which has a high morbidity and mortality (about 10%-20%).So far ,there has been no effective measurement to dealing with AP mostly because of the unclear mechanism of it's initiation and development.After initiation of AP, the noninfectious destruction of pancreatic parenchyma quickly induces an inflammatory response at the site of injury. Leukocytes that invade the pancreas and macrophages were activated and became the predominant source of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF a), interleukin 1 beta (IL-1β).Then a cytokine cascade was induced and systemic amplification was occurred. This...