Preliminary Study On The Effects Of Neurodevelopmental Toxicity In Mice Exposured To Malathion

BackgroundMalathion belongs to a class of insecticides known as organophosphates(OPS). The main target of Malathion is the central nervous system. Recently the study showed that chronically and exposured to low dose malathion seemed to be more susceptible to recognization and psychology deficts, developing Parkinson's disease and other neurodegenerative disease. Still, there is not sufficiant to assess pohential neuro developmental following long-term exposure to malathion at low dose.ObjectiveTo observe the neurobehavioral developmental effects of low dosage exposured to malathion in mice by a series methods of behavior. lipid peroxidation in brain, meanwhile, acetylcholinesterase activity in hippocampus and the levels of intracellular calcium were measured.MethodsTo observe the effects of neurodevelopmental toxicity in mice early exposured to malathion. All mice except controls were intraperitoned different doses of malathion (0.05, 0.5, 5 mg·kg^-1, i.p.) every other day on postnatal day (PND3-13), the PBS- and DMSO- treated mice served as controls. After exposured to malathion, the following signs were observed: physiological growth, sensory movement and loctomotion and harmony ability of little mouse, spontaneous motor activity by spontaneous motor apparatus, open field, wire suspension and balance beam test detect balance capability, anxiety by black-white alley and plus maze, species-typical behaviors by burrowing and...