| Cadmium (Cd) is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure. In mammals, it exerts multiple toxic effects and has been classified as a human carcinogen by the International Agency for Research on Cancer. Cadmium is a toxic metal with an extremely long biological half-life of 1530 years in humans. Taurine (2-aminoethane sulfonic acid) is present in the brain, heart, liver and kidneys of mammals in high concentrations and represents one of the most abundant free amino acids in the body. Despite its abundant distribution, the biochemical and physiologic function of taurine is not fully understood. To study the protective effects of taurine in DNA damage of heavy metal, this article chooses cadmium chloride (CdCl2) as the subject.Firstly, the single cell gel electrophoresis assay was used to the DNA damage in the whole-blood lymphoid leucocytes of the rats. The low cadmium concentrations may damage DNA strand breaks, the increasing doses of cadmium chloride resulted in a dose-dependent. Compare to the corresponding CdCl2 groups, the pre-treatment groups and the co-treatment groups decreased significantly the DNA damage, moreover the pre-treatment groups were superiored to the co-treatment groups. When the advance taurine was be given the lymphoid leucocytes rate of DNA damage, the significantly decreased in each group (P<0.05).Secondly, anti-free radicals examination show as a result CdCl2 groups decreased free radicals clearance rate than control group (P<0.05). Pre-treatment groups were more significant the rate of clearance hydroxyl free radical than co-treatment group.To study the mechanisms intensively, a series of hypothesis were tested. In order to discussing the mechanisms of taurine against the cadmium chloride injury, we selected the activity of GSH-Px enzyme and SOD content in mice liver cells. The groups were decreased the activity of GSH-Px enzyme than the control group...
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