Study On Expressions And Clinicopathologic Significance Of Correlative Metastasis Genes BRMS1 And CD44V6 In Oral Squamous Cell Carcinoma

Objective: To investigate and analyze the expressions of BRMS1 (breastcancer metastasis suppressor 1, BRMS1)mRNA and CD44V6mRNA in oral squamous cell carcinoma (OSCC) and normal oral mucous membrane near the tumors, and to explore their relationships of the expressions as well as the clinicopathological factors. Analyzing their relationships will accelerate and improve the level of diagnosis and treatment, even estimate prognosis of the OSCC patients, which could 'provide two significant targets of molecular biology and could establish theoretical and practical foundation for deeply studying the new gene BRMS1.Methods: At first, these OSCC samples and the normal oral mucousmembranes near the tumors were collected and reserved immediately in -80 ℃ refrigeratory. Then the expressions of BRMS1mRNA and CD44V6mRNA in 38 cases of OSCC tissues and 20 cases of normal oral mucous membranes near the tumors were carried out by an approach of semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). By using 1 D Image Analysis software, the electrophoresis...