The Expression And Their Clinical Significance Of ET-1, COX-2 And VEGF In Gastrointestinal Stromal Tumors

Objective: Determining the expression of ET-1, COX-2 and VEGF in gastrointestinal stromal tumors (GIST) and analyzing some aspects as following: 1.The relationship between the expression of ET-1, COX-2 and VEGF in GIST and the clinical pathology characteristics of GIST. 2.Analyzing the relationship among ET-1, COX-2 and VEGF and between the three angiogenesises and the biological behaviors of GIST. 3.For the purpose on providing scientific basis for the diagnosis, therapy and prognosis evaluation of the GIST. 4.In order to provide theory basis of effectively adjunctive therapy through animal experiment by inhibiting vascuiarization lately. 5.Approaching more scientific grouping methods of GIST.Methods: 54 GIST patients whose pathological diagnosis was defined were selected from general surgery department of Shandong provincial hospital from January of the year 2001 to January of the year 2005. We took slices from GIST paraffin blocks preserved in pathological department and determinate the protein expression of ET-1, COX-2 and VEGF in it through immunohistochemical method(S-P method). Experimental data were analyzed together with the clinical pathological datum.