The Influencial Factors On Occurrence Of Hepatitis B Case In Children

Objectives: For providing testimony to control hepatitis B (HB)in children aged less than 15 years old , we researched influencial factors on occurrence of hepatitis B cases and HBsAg(+) cases in children.Methods: According to the investigation about HBsAg serological epidemiological sudy in Fujian of 2003 by stratified random duster sampling, we selected six county based on HBsAg(+) rate as studying unit, and designed the research with 1:2 case-control study . In research on occurrence of HB cases in children ,We selected HB cases occurred in 2005 and aged less than 15 years as cases group ,and selected children who was same gender and same villige and age difference less than 2 years and no consanguinity relation as control objective. In research on occurrence of HBsAg(+) cases , We selected HBsAg(+) cases found in study of 2003 as cases group , and selected HBsAg(-) children who was same gender and same villige and age difference less than 2 years and no consanguinity relation as control objective. We enquire with unite questionnaire , and input database after coding .Then we conducted cox regression on single factor and multi-factors with spss 13.0. In order to know the actual condition of HBV immunization coverage rate and its influential factors in Fujian Province, we investigated 4032 children who were born between Jan. 1, 2001 and Sept. 30, 2003 by PPS.Results: The case-control on occurrence of HB cases in children based on single factor showed as follow. Immunization history on HB vaccine β =-2.259, HBsAg(+) before occurrence of HB β =-4.103, Intravenous translation history β = 1.005, Intramuscular injection or Intravenous injection history β =1.005, Intrafamiliar HB case or HBsAg(+) case β = 1.366. The case-control on occurrence of HB cases in children based on multi-factor showed as follow.