The Relationship Between Insulin Level And Mild Cognitive Impairment: A Clinical Study In Type 2 Diabetes Subjects

Objective: To investigate the relationship between Insulin level and mild cognitive impairment (MCI) of type 2 diabetes and risk factors for mild cognitive impairment. Methods: We collect 101 type 2 diabetes subjects. According to the clinical diagnostic criteria of MCI which made by Petersen and his colleagues, subjects were divided into two groups: MCI and normal cognitive. All admitted subjects were evaluated with MMSE, GDS, CMS,ADL. The level of insulin, HbA₁C, blood tests, blood pressure, cardiogram, Cranial Computed Tomography was carried out. Incording to the course of diabetes, 101 subjects were divided into four groups: neopathy, the course of disease less than one year, the course of disease during one to five years, the course of disease more than five years. Independent T-test, significance test, chi-square test , related and regression analysis were performed to the basis of the date. Results: 1, The MCI incidence (32. 7%) of diabetes is obviously higher than the normal older. 2, For the diabetic patients with MCI, the level of insulin in the first, second and the third hour afer meal is significant higher than those normal cognitive (P<0. 01). During MCI and diabetic patients, inverse correlation is significant in the level of insulin which in empty stomach and the...