Primary Study On The Expression Of Kiss-1,MMP-9,NF-κBp65 In Ovarian Tumour

BackgroundOvarian cancer is a common malignant tumor in women reproductive system. With the fatality rate heads the list of the gynecological malignancies, ovarian cancer has been a great menace to women's lives and health. Because it is difficult to diagnose in early stage and easy to metastasize, its incidence and mortality rates are almost identical even though comprehensive treatment, including cytoreductive surgery and cisplatin-based combination chemotherapy. The 5-year survival rate of ovarian cancer is still very low, about 20%-40%. Therefore, how to inhibit invasion and metastasis will be the effective approach to improve effect of treatment. It is well-known that the development of cancer is the result of series of molecular mechanisms. Genomic alterations have been found to be frequently associated with development and metastasis of malignancies. At present, we had found about 10 kinds of anti-metastasis genes. Their capital function are anti-metastasis. The Kiss-1 gene is a conspicuous tumor metastasis-suppressor gene. Kiss-1 gene has a negative correlation on MMP-9, by the way of reducing the combination of NF-κB p65 and MMP-9 promoter, and therefore, reduce the expression level of MMP-9.ObjectiveThe study is aimed to define the status of Kiss-1 expressed in ovarian tumor, and the relation with clinical stage, histological grade, histological classifications, lymphatic metastasis and the correlation among Kiss-1, NF-κB p65, MMP-9 during evolution of the primary ovarian epithelial tumor.