Changes Of Serum Total Antioxidant Capacity And Malondialdehyde Concentration In Type 2 Diabetes With Dabetic Carotid Disease And Diabetic Retinopathy

Objective: To investigate the role of oxidative stress in diabetic carotid disease and diabetic retinopathy. Methods: Serum level of the total antioxidant capacity(TAOC) and Malondialdehyde(MDA) were measured in 92 patients with type 2 diabetes.Meanwhile,fasting blood glucose, glycosylated serum protein, glycohemoglobin,serum creatinine, blood uric acid, fibrinogen and lipids were detected. The diabetic carotid disease was detected by colour Doppler and diabetic retinopathy was detected by fundus fluroescein angiography.The patients were divided into three groups, the diabetes group without diabetic carotid disease and diabetic retinopathy(DM1)(n=30), the diabetes group with diabetic carotid disease(DM2)(n=30), the diabetes group with diabetic carotid disease and diabetic retinopathy(DM3)(n=32). Results: (1)TAOC level was negative correlated with MDA level(r=-0.312,P<0.01). (2)TAOC concentration was evidently lower in DM2 and DM3 than that in DM1(P<0.05) .(3)MDA concentration in DM2 and DM3 was significantly higher than that in DM1(P<0.05) .MDA concentration in DM3 was significantly higher than that in DM2 (P<0.05). Conclusion: Oxidative stress may participate in the development of type 2 diabetic micro- and macrovascular complications.