The Applications Of Excipients In The Preparation Of Pharmaceuticals

The pharmaceutical are composed of various diluents bases and adjuncts, which are essential materials and important parts in pharmaceutics. They play a key role in developing dosage forms and pharmaceutical industry production. Pharmaceutical excipients can not only provide some dosage forms of drug, but also increase therapeutic effects and reduce side effects. Further, the optimization and design of formulation as well as the research and development of dosage form all depend strongly on the selection of excipients. The study of new dosage forms advances the development of new excipients in recent forty years, so they have a close relation and depend strongly on each other.This review paper discussed the important function of excipients on dosage forms, and described the relationship between excipients and absorption, and the adverse drug reactions caused by excipients as well. There is a positive correlation between drug and excipients, and the excipients play an important and positive role in applications of drugs. Some pharmaceutical excipients, such as solvent, attenuant, adhesive material, disintegrating agent, lubrication and water soluble polymer of solid dispersion, have a considerable impact on drug absorption. Adverse drug reaction could be caused by the non-rational use of some excipients, thereby; the article summarized some adverse drug reactions induced by excipients and the attention for the use of excipients in dosage form design.Comparison has been carried out between domestic and foreign excipients, including the description, usage frequency, quality standard, detecting methods, scientific research, application study and production operations.Through the contrast research on the description and usage frequency, the causes of domestic preparations inferior to foreign ones were analyzed. Although the Medical Subsidiary GMPGuide was issued, domestic excipients are scant of unified quality standards, and there is still a big gap compared with foreign ones. The detection methods for excipients are single and detecting instruments are backward, which cause a great quality discrepancy among the excipients.Through the contrast research on the application study and production operations, the paper finds that domestic excipients are all imitations, and the research is mostly concentrated traditional old dosage form and repeated at low level. Besides the research depth is not inadequate, and theoretical research of application is still blank,which need to be further investigated.Application of the excipients in dosage forms development, e.g. in the solid preparation as well as inclusion compound, sustained/controlled release preparations, transdermal and targeting drug delivery systems, solid dispersion and mucosal absorbefacient, were introduced in this review. The article also presents the applications of some new supplementary agents such as hypromellose, cellulose microcrystallisate, polyacrylic resin in detail, and the development suggestions on also were described.In the end, the paper gives some advice on the development of supplementary agents industry in China. We hope that China's pharmaceutical excipients manufacturers will improve the product quality constantly, enhance independence innovation ability, find out for the development of domestic enterprises, and enabled new excipients continued development and application. Through the quality.control and the application of technology services, the competitiveness of strength and service competitiveness strength are hoped to be improved and enhanced. Then some measucements, e.g. specialization and multi-variety series of production, application of scientific, and quality service, international market development trends, must to be administered to enable the pharmaceutical excipients play a greater role in development of new dosage form, and achieve better social and economic benefits.