The Microsatellite Instability And Loss Of Heterozygosity In Laryngeal Squamous Cell Carcinomas

Our aims are to study the incidence of microsatellite instability and loss of heterozygosity in larynx and pharynx squamous cell carcinoma at the domains of 8p23.2,9p21.1,3p24.3. and the relationship with morbility of laryngeal carcinoma . Microsatellite is a kind of simple repeat sequence.they distributed at human genome randomly.Microsatellite instability and loss of heterozygosity are found in all kind of tumours. The gene linked with microsatellite sequence can be screened and defined by Comparining the microsatellite alloeosis of tumorous tissue and no- rmal tissue. Also antioncogenes and oncogenes participated canceration can be found by this way. Oncogene comes from the mutation of normocell gene which regulates the proceeding of Cellular growth and development .like Cellular proliferation and multiplication. Oncogene can made cell possess anomal-multiplication capability. On the contrary, antioncogene accommodates the Cellular growth negatively.For example ,the p53 will loss...