Clinical And Pathological Study Of Serous Borderline Ovarian Tumor

Objective: To study the expression of Ki-67,E-cadherin and Mesothelin in serous borderline ovarian tumors (SBOT) and analyze the relationship between the expression of these markers and the clinicopathological parameters of SBOT, and combine its morphology character to find effective markers for diagnosis, in order to distinguish SBOT from malignant ovary tumor, further to predict its prognosis and adopt appropriate clinical managements.Methods: Immunohistochemistry was used to detect the expression of cellular proliferation and metastasis related factors(Ki-67,E-cadherin and Mesothelin) in 28 cases of serous borderline epithelial ovarian tumors. Moreover, their status were compared to 30 cases benign and 30 cases malignant tumors.Results: 1. The expression of Ki-67 protein were higher in SBOT than that in benign serous tumors and were lower than that in serous carcinoma , the expression of Ki-67 protein had statistical significance between every two of the three groups.2 The positive rate of E-cadherin protein in benign ,borderline and malignant of ovarian tumor was 90.0%,78. 6% and 56.7%. In SBOT, the expression of E-cadherin protein was higher than that in benign serous tumors and were lower than that in serous carcinoma, but there was no significance difference compared to benign or malignant group. 3.The positive rate of protein in benign ,borderline and malignant of ovarian tumor was 20.0%, 75.0% and 86.7%. The immunostain of Mesothelin protein was no significantly higher in serous carcinoma than in SBOT. Conclusion:The expression level of Ki-67, E-cadherin and Mesothelin are correlated with the pathological character and clinical behavior of SBOT. Ki-67 can indicate the cellular proliferation its over-expression may contribute to enhance the malignant potential of borderline ovarian tumors, these patients should be nearly follow-up. E-cadherin is highly expressed in SBOT, demonstrates that SBOT generally behave in a benign fashion. Mesothelin is a new marker of the ovary tumors,it may play an important role in the development of SBOT, may be linked with peritoneal implants. In a word, Ki-67 and E-cadherin are useful to the distinguish between SBOT and ovarian carcinoma.