The Study Of The Value Of Bone Lost Of Mice Ovariectomized And The Influence Of Mechanical Load Of Mouse Tibia

Osteoporosis is a worldwide, has drawn increasing attention to the health problems. About 200 million people worldwide suffer from osteoporosis,and it is becoming the seventh most popular disease in the world. The latest research indicates that the elderly in our country that has been suffering from the endemic disease osteoporosis. But until now there is no good way to treat this disease. And we have no effective measures to help the bone has osteoporosis to restitution. Therefore, , it is particularly important to correctly understand it and prevent the disease to happen early. On the study of human bones,people have spend more than a century on it, the exerciseing therapy has got wider acceptance on the treatment of osteoporosis. By changing the mechanical environment of bones, it can hasten bone remodeling. So we can easily realize the purpose of prevention and treatment of osteoporosis. Osteoporosis is a common diseases to astronauts, the elderly and in postmenopausal women, and bring a lot of trouble to women's health all over the world. Removing the ovary of rats is a better model of osteoporosis of the current scientific research. Through the experiment, we try to know the ovariectomized rats'tibial mechanical properties. And under the same conditions. We remove the ovary of the rats and force the rat to do exercise for one month,then we want to make some comparition if the elastic modulus of trabecular bone and cortical bone of the rats make any change.Due to the lack of estrogen after menopause so many women sufferd from osteoporosis and bone fractures. We have so many patients like this which bring a lot of trouble to the older women all over the world . It has been widely accepted that do exercise can treat and prevent osteoporosis from happening. But we still got no conclusion for how much exercise is good to treat and prevent osteoporosis. The study in this article is based ovariectomized rats,apply quantitative, a regular load to the tibia of the rats. At present, no one has done something on this work.When people get old it is easy for them to suffer from osteoporosis. Both mechanical usage and biological factors have their contributions to this problem. Most aging adults lose momentary muscle strength and the intensity of their physical exercise becomes weaker. The effects of ageing, menopause, drug treatment are known as biological factors, which could modulate the system by means of changing mechanical thresholds, or changing the intensities of certain signals. The computational model for osteoporosis can provide theoretical basis and computational method for the treatment and prevention of osteoporosis. However, little has been done in this aspect of research all over the world. Hazelwood et al. put forward a mechanical model of bone remodeling, which obtained different dynamical response in overload and disuse, but it was difficult to realize the numerical simulation of osteoporosis caused. Hernandez and his colleagues put much stress on biological factors, such as BMU activation frequency,bone-remodeling space, peak bone mass, menopause, mineralization lag time to bone loss.Through the experiment, we get the following conclusions : 1.Exercise can prevent bone loss in ovariectomized rats. It is also good to maintain bio-mechanical properties; 2. From the viewpoint of mechanics, we get the elastic modulus of rats trabecular bone and cortical bone of experimental animals more objective. After scientific experiments to raise the reference value. And the experimental results, well reflect the actual situation envisaged in the basic agreement and prior to the test. For the prevention and treatment of osteoporosis in postmenopausal women groups, and provide a theoretical basis and methods.