The Clinical Research Of Electro-acupuncture Treatment On The Patients With Acute Craniocerebral Injury And Coma

Objective: To observe the effect of electro-acupuncture on the levels of Interleukin-8(IL-8) and soluble intercellular adhesion molecule 1(sICAM-1) in the cerebrospinalfluid(CSF) and tumor or necrosis factor alpha(TNF-a) in the blood of patients withacute craniocerebral injury and coma and to investigate its cerebral protective mechanism.Methods Forty cases with STBI were randomly divided into the treatment group (20cases) treated with electro-acupuncture besides the conventional therapy from the first dayafter their admissions and the control group (20 cases) treated with the conventionaltherapy. The levels of Interleukin-8 (IL-8) and soluble intercellular adhesion molecule1(sICAM-1) in the cerebrospinal fluid(CSF) and tumor or necrosis factor alpha(TNF-a) inthe blood of were measured by enzyme-linked immunosorbent assay (ELISA)technique on the 1st,.2nd, 3rd, 5th, 7th day after injury.Meanwhile to observe the change ofGCS,ability to speak and the ability to move on the 1st,.2nd, 3rd,5th, 7th day after injury.Results:①In the control group the levels of IL-8 and sICAM-1 in the cerebrospinalfluid(CSF) and TNF-a in the blood were significantly increased on the 1st day afterinjury; the highest level was got on the 2nd day after injury,they decreased on the 3rd,5thday and were in the normal range on the 7th day;②In the treatment group,the levels ofIL-8 and sICAM-1 in the cerebrospinal fluid(CSF) and TNF-a in the blood increasedon the 1st day after injury while they decreased on the 2nd,3rd and got to the normal rangeon the 5th day after injury;③The levels of IL-8 and sICAM-1 in the cerebrospinalfluid(CSF) and TNF-a in the blood of treatment group were significantly lower than that ofthe control group on the 2nd, 3rd and 5th day after injury respectively (p＜0.05);④Thescores of GCS of treatment were higher than that of the control group on the 2nd,3rd,5thand 7th day(p＜0.05);⑤The scores of ability to speak of treatment were lower than that of the control group on the 3rd,5th and 7th day(p＜0.05);⑥The scores of ability to movetreatment were lower than that of the control group on the 7th day(p＜0.05).Conclusion: Electro-acupuncture can obviously reduce the inflammatory reaction forthe patients with acute craniocerebral injury, consequently it alleviates secondary braininjury. It contributed the reservations of consciousness and ability to speak and move. Itmight contribute to a new therapeutic strategy for cerebral protection.