| Objective: To observe the therapy effect with the combination of Jiaweisijunzi prescription and cetirizine tablets of perennial allergic rhinitis of deficiency of the spleen-qi, and the changes of serum Total IgE(TIgE),interleukin-4(IL-4) and interleukin-5(IL-5). Taking cetirizine tablets group as the control, to objectively evaluate the efficiency and safety of Jiaweisijunzi prescription in treating the perennial allergic rhinitis of deficiency of the spleen-qi, and further, discuss the mechanism of action.Methods: 60 patients with perennial allergic rhinitis of deficiency of the spleen-qi are randomly divided into two groups with 30 patients each. The treatment group was treated with the combination of Jiaweisijunzi prescription and cetirizine tablets, while control group was treated with cetirizine tablets only (without Jiaweisijunzi prescripton). After 30 days of treatment, Both groups were observed the effects in improving clinical syndromes and the serum level of TIgE, IL-4 and IL-5.Result: (1)The total effective rate of curative effect was 73.3% in treatment group, while 43.3% in control group. There was significant difference between two groups after treatment (P＜0.05).(2) Both groups can reduce serum level of Total IgE (P＜0.01), the comparison of both groups after treatment showed no significant difference(P＞0.05).(3) Both groups can reduce serum level of IL-4and IL-5 (P＜0.01), and the difference between the treatment group and the control group was significant (P＜0.01)。Conclusion: Jiaweisijunzi prescripton had extract curative effect in PAR, it was related with which can reduce serum level of TIgE,IL-4and IL-5.It can improve the organismof the immunity mechanism, and further, improve the clinical symptom. It is the safe effective drug of traditional chinese medicine.
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