Analysis Of Serum Liver Fibrosis Index Of Fatty Liver

Objective to explore the characteristic of serum liver fibrosis index in the patients suffering from fatty liver in taiyuan,and analyse possibly correlation factor in liver fibrosis index alteration.Methods(1)Fatty liver group:the 100 eases diagnosed by B ultrasonography come from taiyuan city,exclude the patients with chronic hepatitis B and C,cholecystitis and pancreatitis, diagnosed according as the diagnostic standard of China with alcolhol liver disease and nolalcolhol liver disease,The 40 healthy subjects without faty liver as control.(2)Record age,gender,excessive alcohol consumption,diabetes,hypertension disease,high triglyceride,high cholesterol,measured their blood pressure,height,weight,,accumunate body mass index(BMI).(3)blood samples were collected from limosis venous blood,separate serum,-20℃saved.(4)Use the biochemical methods to measure fasting plasma glucose(FPG),triglyceride(TG), cholesterol(CHOL),alanine aminotransferase(ALT)and hyaluronic acid(HA),laninin(LN), procollagenⅢ(PCⅢ),collagen IV(CIV),glycine(CG)。(5)Chi-square test was used in the comparison of enumeration data;measurement data was tested by the normality test,normal distributation data of them were expressed as mean±SD, the data that was not normal distributation were expressed as rank sum test,We used multiple Linear regression to assess the relationships between serum liver fibrosis index and other indexs,all data was statisticed with software spss13.0.it is signicant differences when P＜0.05。Results(1)The general comparation between the fatty liver patients and the control:rate of Age and gender is not signicant differences。alcohol history,obesity,diabetes,high triglyceride,high cholesterol are signicant differences(P＜0.05).(2)Comparison of the serum indexes between the 100 fatty liver patients and the control:FPG, TG,TC,ALT,HA,LN,PCⅢ,CIV,CG can be statistically significant between the two groups (P＜0.05)(3)Comparison of serum indexes abnormal rate of two groups,abnormal rate of FPG,TG,TC, ALT,HA,LN,CIV,CG are statistically significant(P＜0.05),abnormal rate of PCⅢis not statistically significant。CG is the most significant serum indexes,then is TG,FPG,ALT, TC;HA is the most significant serum fibrosis indexes,then is LN,CIV。(4)HA is correlated with age(≥50),alcohol history,male,increase of ALT,hypertension disease,increase of GC;LN is correlated with obesity,alcohol history,diabetes;CIV is correlated with,high triglyceride,high cholesterol,increase of ALT;PCⅢis correlated with age(≥50),hypertension disease,,high triglyceride,high cholesterol.conclusion:The analysis of the clinical datas,serum indexes of fatty liver,We find that(1)The features of the metabolic syndrome such as obesity,diabetes,high triglyceride,high cholesterol disease exist in fatty liver disease,some of these show the increase of the serum fibrosis indexes.(2)The serum indexes and serum fibrosis indexes between the two groups are statistically significant,the most sensitive fibrosis index is HA and is LN,CIV,PCⅢ.(3)The results of analysis of Multiple Linear Regression:male,age≥50,alcohol history,obesity, hypertension disease,diabetes,high triglyceride,high cholesterol disease,increase of CG,increase of ALT might be the possible factors that can stimulate fatty liver to fibrosis.