| Objective: The purpose of our studying was investigating the influence of creatinine clearance rate on amino-terminal pro-B-type natriuretic peptide and carboxyl terminus natriuretic peptide in the patients with congestive heart failure. Which were with or without renal inadequacy, and the dependability which was between ultrasonic cardiography and creatinine clearance rate.Methods: NT-proBNE BNP and serum ereatinine were detected from 82 patients with CHF and 18 health people. At the same time, ultrasonic cardiography were detected in these people, that including left atrial dimension (LAD), interventricular septum thick(IVST), left ventricular end-diastolic dimension(LVEDD), left ventricular end-systolic dimension(LVESD), left ventricular ejection fraction(LVEF) and so on.Result:1. NT-proBNP was positive correlative with LVEDD (P＜0.001) and BNP (P＜0.001), negative correlative with LVEF (P＜0.001) and creatinine clearance rate (P＜0.001). BNP was positive correlative with LVEDD (P＜0.001), negative correlative with LVEF (P＜0.001), creatinine clearance rate was negative correlative with LVEDD (P＜0.001) and NT-proBNP(P＜0.001).2. In the multiple regression analysis, creatinine clearance rate was a independent correlation factor of NT-proBNP, not BNP3. Through the ANOVA; F test; With the aggravation of renal function, the concentration of NT-proBNP heightened gradually (P＜0.001). And the same situation was happened in the ratio of NT-proBNP to BNP (P＜0.001) the concentration of BNP in the stage of compensation of kidney failure, decompensation compensation, kidney failure and the normal had no difference (P＞0.05), but the urinemia was higher than the kidney failure (P=0.0475).Conclusion:1 Creatinine clearance rate were conspicuous linear correlative with LVEDD and NT-proBNP2. With the aggravation of renal function, the concentration of NT-proBNP heightened gradually in the patients with CHF incorporation with renal inadequacy. But the change was very little in the concentration of BNP.
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