Study On Theeffect Of Treatment Of Invigorating Spleen And Promoting Blood Regulating Qi On TGF-β₁ MMP-1 TIMP-1 Of The Hepatic Fibrosis Rats

Hepatic fibrosis is a commom response to chronic liver injury rom many causes,and the commom way to liver cirrhosis for many chronic liver diseases.At the present some researches have demonstrated that anti-fibrous of liver texture is the key point to HF,At the same time,restrain the expression of Transforming growth factorβ₁ and MMP-1and TIMP-1 are all important in the anti-fibrous of liver texture treatment process.The research based on the basic theory of TCM,set up"the treatment of invigorating spleen and promoting blood by regulating qi",and choose"Chai Hu Gui Zhi Tang",and take experiments.This paper studies the anti-fibrous mechanism from tissue.The result show that:1. Our research injected Ccl₄ into back to make liver deficiency rat model,according with liver deficiency syndrome and Hepatic fibrosis from symposium,physical sign and tissue form,so this rat model is successful.2. HE pigmentation result show:"The treatment of invigorating spleen and promoting blood by regulating qi" can recover texture fibrous of hepatic fibrosis,and the method can raise ability of fibrous solution.3. The treatment depress obviously expression of TGF-β₁,the mechanism of the treatment is that it can cut off irritation of liver,and reduce synthesis and improve solution of ECM, so it can resolve fibrous of liver.4. The treatment can improve content of MMP-1,and drepress obviously of TIMP-1,the mechanismis that it can cut off PCI andPCâ…¢,and improve solution of ECM, so it can resolve fibrous of liver. 5. The result show that with"The treatment of invigorating spleen and promoting blood by regulating qi",and choose"Chai Hu GuiZhi Tang"which make a new gateway to therapy Hepatic fibrosis.