The Efficacy Of Chelating Agent L07 For Removal Of Depleted Uranium And Basical Safety Assessment

Background and Objective: Nowadays, more and more people are concerned about the problem of gas dispersoid resulting from depleted urianium (DU) weapons on environment and human health. As same as the medical treatments of internal contamination of other radionuclides, decorporation is one of the effective measures to decrease the harm of internal contamination . However, a lot of chelating agents for DU still have some insufficiencies in removal effect or security presently. The objective of this study was to investigate the DU decorporation effect through using a new compound L07, to assess the security initially, and to offer the theoretical and experimental evidence for the development of the new drugs which are high-performance and low-toxicity and used to remove DU in vivo.Material and Method: We used DU powder to prepare uranyl nitrate which was injected in abdominal cavities of rats to establish animal models , physiological saline as negative contral, and sodium bicarbonateand and calcium trisodium diethylenetriamine pentoacetate(DPTA) as positive control. We tested uranium in some main tissues and organs (heart, liver, spleen, lung, kidney etc.) by laser liquid fluorimetry, and evaluated the DU decorporation effect of L70. At the same time, we observed acute toxicity in mice administrated by different ways (intramuscular injection, intrperitoneal injection and intragastric administration). The long-term toxicity of L70 were tested through observing body weight, observe coefficient, hematol parameter, biochemical parameter and so on.Result: After rats exposed anticiatorily to DU was administrated by L07 once or more times, DU concentrations of main tissues and organs obviously decreased. Therefor , the DU decorporation effect of L07 has an advantage of DPTA and NaHCO3. The results of acute toxicity test shows that the LD₅₀ of L07 is 183.7mg/(kg-bw) and the 95% confidence interval is 122.3～275.7mg/(kg-bw).In 90 days feeding trial, we didn't find that L07 displayed obvious toxicity in mice. Conclusion: L07 is low-venenosus and high-performance. It may be developed to be a new chelating agent to treat internal DU contamination.