Relationship Between Plasma P-selectin And Insulin Resistance In Patients With Metabolic Syndrome Complicated Coronary Artery Disease

Objective To investigate the difference of plasma sP-selectin level in patients withmetabolic syndrome and metabolic syndrome complicated coronary artery disease, toanalyze its relationship with insulin resistance, to explore its contribution in developmentto coronary artery disease from metabolic syndrome.Methods Fasting plasma sP-selectin levels were measured in 17 MS patients, 40MS+CAD patients and 19 healthy controls using cytometric bead array combined withflow cytometer, fasting plasma insulin levels were measured by means of enzyme linkedimmunosorbent assay method. Other information on conventional clinical features of MS,such as waist,body height,weight,fasting blood glucose and blood fat were collected, theinsulin sensitivity index (ISI) and body mass index were calculated.Results (1)There was significant difference in sP-selectin concentrations betweencontrols (25.1±3.6)μg/L, subjects with MS(33.1±5.1)μg/L and subjects with MS+CAD(41.3±8.4)μg/L.(2)Correlation analysis results suggested that the fasting plasma P-selectinconcentration was related to insulin sensitivity index(r=-0.460,P＜0.05), and the metabolicparameters including body mass index (r=0.402, P＜0.05), low density lipoproteincholesterol (r=0.406, P＜0.05), waist (r=0.538,P＜0.05) and fasting insulin (r=0.478,P＜0.05). (3) Logistic regression analysis indicated a statistically significantrelationship between sP-selectin concentration and ISI(r~2=0.212, P＜0.05),waist(r~2=0.290,P＜0.05), fasting insulin (r~2=0.228, P＜0.05), LDL (r~2=0.165, P＜0.05) or body massindex (r~2=0.162, P＜0.05).Conclusion (1) sP-selectin concentration was highest in patients with MS+CAD,and increased in patients with MS; (2) Plasma sP-selectin concentration was significantlycorrelated with insulin resistance. (3) sP-selectin may play a key role on development tocoronary artery disease from metabolic syndrome, and has potential clinical value.