Microsatellite In Bladder Cancer Recurrence And The Early Diagnosis Of Clinical Significance

Objective: Discussion microsatellite instability in bladder cancer earlydiagnosis of, exfoliated cells in urine assessment of microsatellite instabilityin bladder cancer recurrence diagnostic value and potential clinicalsignificance. Microsatellite analysis of the changes in tumor occurrence andthe early evolution and the role of recurrence, Evaluation of the tumor in itsearly diagnosis and recurrence diagnostic value.Methods: (1) Using seven microsatellite markers, using silver stainingmethod, 33 patients with bladder cancer tumor tissue, Bladder lavage dregsof the experimental group and 10 cases of non-patients with bladder swollenbladder tumor tissue, Exfoliated cell tumors of the control group patientswere detected in tumor tissue and urine sediment chromosome MSI.(2) 68pairs of postoperative follow-up of bladder cancer in urine samples and 20normal controls were chosen seven of the same site, silver staining methodused for microsatellite instability testing, analysis of parameters includingthe availability of hematuria, size, WHO classification and sevenmicrosatellite loci markers.Results: 1. Early diagnosis of bladder cancer(1) 33 cases of patients withearly bladder cancer in urine MSI positive rate of 66.7% (23/33)(2) EarlyBladder Cancer Microsatellite instability and changes in the tumor stage,grade and age (P＞0.05)(3) 10 cases of normal urine sediment checks werenegative.2 Diagnosis of bladder cancer recurrence (1) 68 cases of bladder cancerwere followed up after 20 patients relapsed, recurrence in 17 patients withpositive MSI (85.00%), and 15 cases of hematuria specimens(2) Detectionof postoperative follow-up urine exfoliated cells MSI diagnosis of bladder cancer recurrence, the sensitivity, specificity, and positive values wereforecast 85.00%!82.50% and 83.33%(3) Recurrence of bladder cancermicrosatellite instability and changes in the tumor stage, grade and age werenot related.Conclusion: Exfoliated cells in urine detection of microsatellite instabilitycan be as early recurrence of bladder cancer and bladder cancer in anon-invasive diagnostic and screening means...