Study On Relationship Between CT Staging And CT Enhancement Of Gastric Cancer And Tumor Angiogenesis

Objective To study relationship between CT Staging and CT enhancement of gastric cancer and tumor angiogenesis, provide useful message for clinic therapy. Materials and Methods Enhanced two-stage spiral .CT scanning was given before operation to 30 cases who suffered from gastric cancer and were confirmed pathologically after operation. The 30 cases include 24 men and 6 women,their average age is 63.CT enhancement values of affected area were determined. Tumor specimens of 30 cases were collected. Two-step CD 34 mono-clone antibody and VEGF mono-clone antibody immunological and histo-chemical staining were performed on corresponding research area. TMN and CT staging were also performed based on clinical, CT and pathological findings. Statistical research was carried out on CT enhancement values, CT staging, TMN staging, pathological grading and results of CD 34 and VEGF staining. Results Conformity rate of TMN staging and CT staging of 30 cases of gastric cancer is 90%. CT enhancement value is positively correlated with TMN and CT staging. CT enhancement value is positively linear correlated with MVD. Its equation is Y=49.4125+0.5067X. Difference of CT enhancement values of VEGF high and low expression groups is significant with P<0.05. There is no relation between pathological grading and CT enhancement value with P>0.05.Conclusion Staging can be made by CT presentation before operation. CT enhancement value can reflect tumor angiogenesis of gastric cancer. Pathological grading has no direct assistance in study of CT enhancement value.