Hyperandrogenism In Polycystic Ovary Syndrome

Objective:According to Revised 2003 European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria,the study was to investing the concentration of the androgenic hormone and the relationship in biomedical parameters.Methods:thirty consecutive patients with PCOS and thirty age matched healthy control women were included in the study.To measure the concentration of follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E₂),testosterone(T),androstene dione(A₄),sulfal-dehydroepiandrosterone(DHEAS),sex hormone-binding globulin(SHBG),fasting glucose(FG),fasting insulin(FIN)and clinic parameters such as age,days of menstrual cycle,body mass index(BMI), waist-to-hip ratio(WHR),Ferriman-Gallway hair graded,mean ovarian volume(MOV),mean follicle count(MFC)and calculated homeostasis model assessment Insulin resistance(HOMA-IR),insulin sensitivity index (ISI),free androgen index(FAI).The obtained data were analyzed by SPSS 11.5 of statistical software.Result:(1)LH,LH/FSH,T,A₄,FAI,FIN,Homa—IRwas significantly higher in the PCOS group compared to the controls(P＜0.05),FSH,SHBG,ISI was significantly lower in the PCOS group compared to the control(P＜0.05),PRL, FG,E₂,DHEAS measurements did not differ between the groups.(2)46.7% patients have an increased T in the PCOS group,and 6.7%in the control. There was great significant differences between the PCOS group and the control(P＜0.05).70%patients have an increased FAI in the PCOS group, and 20%in the control.There was great significant differences between the PCOS group and the control(P＜0.05).20%patients have an increased A₄ in the PCOS group,and 3.3%in the control.There was great significant differences between the PCOS group and the control(P＜0.05).There was not significant differences of DHEAS between the PCOS group and the control(P＞0.05).(3)63.2%patients have an increased T in the hirsute group,and 9.8%in the non-hirsute group.There was great significant differences between the hirsute group and the non-hirsute group(P＜0.05). 73.7%patients have an increased FAI in the hirsute group,and 31.7%in the non-hirsute group.There was great significant differences between the hirsute group and the non-hirsute group(P＜0.05).26.3%patients have an increased A₄ in the hirsute group,and 4.9%in the non-hirsute group. There was great significant differences between the hirsute group and the non-hirsute group(P＜0.05).(4)T,A₄,DHEAS of the obese PCOS group was not significant differences compared to the non-obese PCOS group(P＞0.05). FAI,Homa-IR was significantly higher in the obese PCOS group compared to the non-obese PCOS group(P＜0.05).SHBG,ISI,LH/FSH was significantly lower in the obese PCOS group compared to the non-obese PCOS group(P＜0.05).(5)The quantity of insulin resistance in the increased T group was significantly higher compared to the common T group(P＜0.05). (6)There were not significant differences of A₄,DHEAS between the insulin resistance group and the non-insulin resistance group(P＞0.05).T and FAI of the insulin resistance group was significantly higher compared the non-insulin resistance group(P＜0.05).(7)In PCOS group there were significant correlations between FAI and BMI(r=0.513,P＜0.01),FAI and Homa—IR(r=0.456,P＜0.01),BMI and LH/FSH(r=-0.408,P＜0.05)。Conclusion:FAI is more useful parameter compared T,A₄,DHEAS for the discrimination of PCOS patients and healthy controls.Obese PCOS women have more severe hyperandrogenism,insulin resistance and hyperinsulinism than nomal-weight PCOS women,which may have some health implications later in life.Hyperandrogenism and insulin resistance are consanguineous correlation.