A Study About Relationship Of TCRCα-575A/G Polymorphism With ANCA Positive Vasculitis In Han Nationality Of Chinese Population

Objection To investigate the relationship of T cell receptor constant alpha chain gene(TCRCα)575A/G polymorphism with the clinical and pathologic manifestation of ANCA positive Vasculitis in Han nationality of Chinese Population,.Methods TCRCα—575A/G gene types were determined in the patients and the control group by the PCR-RFLP and the pathology of AASV and ANCA-positive systemic lupus erythematosus were studied.Result(1)In our study,3 genetypes and 2 alleles of the primary and the secondary groups distribute as the same pattern as the control group does(P＞0.05).(2)In the primary group,those with AA genetype behave a remarkably less volume of pre-therapy urinary protein in contrast to those who take AG and GG genetypes (P＞0.05).(3)The rate of gastro-intestinal system involved is significantly lowest in the patients with AA genetype compared with the patients of AG and GG genetypes in the primary group(P＞0.05).There are no significant differences found in either genetype distribution with sex,age,blood pressure, C-reactive protein,serum creatinine,se(?)um albumin,serum uric acid, C₃,C₄.Meanwhile,no significant differences were found in the incidence rate of edema,skin rash,respira.tory damage,arthritis, marasmus,hematuria,hemopoietic system damage.(4)49 cases,including 28 of the primary group and 21 of the secondary one, have complete pathological recordes.The renal pathology of GG-genetype patients contrasting with AA and AG-patients in both primary and secondary groups assume a strikingly less occurrence rate in Mesangial proliferation,respectively(P＜0.05).(5)The primary GG-patients show an obviously lower.TIL comparing to AA and AG patients(P＜0.05).(6)A lower occurrence rate of IgG and Clq deposition was found in the AA genetype patients comparing with those who take AG and GG genetypes in the secondary group(P＜0.05).(7)The age and CRP in the 49 cases had positive correlation with TIL.The urinary protein had positive correlation with serum creatinine.Conclusions TCRCα-575A/G polymorphism might be associated with the pre-therapy urinary protein,likewise the occurrence rate of gastro-intestinal system damage,the mesangial proliferation,the severity of the tubulointerstitial lesions and. immunocomplex deposition in kidney,but might not helpful to estimate the genetic risk and the occurrence rateof systemic lesion symptom except the gastro-intestinal system's.