The Study Of Serum Adiponectin And Related Factors In Type 2 Diabetic Patients

Objective The aim of this study was to investigate the levels of serum adiponectin and related factors in type 2 diabetic patients.Methods 60 diabetic and 30 non-diabetic subjects were fallen into obese-diabetic group (BMI≥25kg/m~2),nomal-weighted diabetic group (BMI＜25kg/m~2) and control group (BMI＜25kg/m~2). Serum adiponectin and insulin were detected by ELISA method and plasma glucose, lipid profiles, HbAlc were measured on fasting samples. BMI and HOMA-IR were calculated.Results The concentration of serum adiponectin was significantly decreased in diabetic group compared with that of the control group. The concentration of serum adiponectin in obese-diabetic group was significantly lower than in nomal-weighted diabetic group. Univariate analysis showed serum adiponectin to be negatively associated with TG (r=-0.225, P＜0.05),BMI (r=-0.697, P＜0.01),FBG(r=-0.323, P＜0.01),HbA1c (r=-0.368,P＜0.01),FINS (r=-0.272, P＜0.01),HOMA-IR (r=-0.351, P＜0.01). Multiple regression analysis including age,BMI,TG,TC,HDL-C,LDL-C,FBG,FINS,HOMA-IR and HBAlc in all subjects showed BMI was significantly independent determinant for serum adiponectin concentration.Conclusion The concentration of adiponectin was significantly lower in serum from type 2 diabetic patients than in nomal subjects. We demonstrated that adiponectin was correlated with obesity, insulin resistance, TG, FBG, FINS, and HbAlc. So we think any treatment which increase adiponectin seems to be beneficial to obesity and glucose metabolism.