The Probable Associated Factors Of Aspirin Resistance In Patients With Coronary Heart Disease

Objective:The study was designed to investigate the optical platelet aggregation and the marker of platelet activation: PAC-1 and CD62P and to learn about aspirin resistance and its probable associated factors.Methods:We enrolled 40 patients with coronary heart disease who complied aspirin 100mg/d at least for 7 days(5 cases with MI,35 cases with angina)and 30 normal controls.We tested for platelet activation by optical platelet aggregation using adenosine diphosphate(ADP)or arachidonic acid(AA),and the marker of platelet activation:PAC-1 and CD62P by using flow cytometry. Results:The prevalence of aspirin resistance in patients with coronary heart disease was 10%and the prevalence of aspirin semi-resistance was 35%.The rate of patients who were with hyperglycemia in aspirin resistant or aspirin semi-responders was higher than that in aspirin-sensitive patients(50.00%vs 18.18%,P＜0.05).The percentage of PAC-1 or CD62P in patients with coronary heart disease(0.95%±0.66%,5.15%±3.63%)were higher than normal controls(0.50%±0.43%,2.65%±2.20%)(P＜0.05).Meanwhile the percentage of PAC-1 or CD62P in patients with aspirin resistance (1.19%±0.80%6.61%±4.19%)were higher than that with aspirin sensitivity(0.76%±0.47%3.96%±2.64%)(P＜0.05).Conclusion:The prevalence of aspirin resistance in patients with coronary heart disease was 10%and the prevalence of aspirin semi-resistance was 35%.Aspirin resistance in patients with coronary heart disease may be associated with hyperglycemia or the marker of platelet activation PAC-1 and CD62P.