Study Of The Levels And The Correlation About High Senstive C-reaction Protein And Plasminogen Activator Inhibitor Type 1 In Patients Of Unstable Angina Pectoris With 2 Type Diabetes Mellitus

Objective: To explore the role and the correlation among the high senstive C-reaction protein , plasminogen activator inhibitor type 1 in Patients of unstable angina pectoris with 2 type diabetes mellitus. Methods: The serum high senstive C-reactive protein and the plasma plasminogen activator inhibitor type 1 levels were measured in 149 subjects, including 40 patients of unstable angina pectoris with 2 type diabetes mellitus (UP+DM), 56 patients with unstable angina pectors (UP) and 53 patients with stable angina pectors (SA). To study the changes and correlation of two inflammatory markers in different groups. Results: Compared with the three groups, Concentrations of hsCRP in the UP+DM group were higher than the UP group (5.18±2.71mg/lvs3.80±1.93rng/l) and the SA (5.18±2.71mg/l vsl.95±0.92mg/l) group, the UP group were higher than the SA group(3.80±1.93mg/l vsl.95±0.92mg/l), there were significant difference; there were significantly different in the levels of PAI-1 among the three groups, while the levels of the PAI-1 showed no difference between the UP+DM group and the UP group, the levels of the PAI-1 in the subjcets with hsCRP>3mg/L (n=68) were (1.73±0.93ng/ml), the levels of the fasting plasma glucose (FPG) in them were(5.85±1.31mmol/l), and the prevelence rate of the unstable angina pectoris were 40.94%;while the levels of PAI-1 with hsCRP<3mg/L (n=81) were (1.15±0.58ng/ml), the levels of FPG in them were (5.12±0.68mmol/l), and the prevelence rate of the unstable angina pectoris were 23.48%; there were significantly different between in two groups. There are positive correlation between the levels of hsCRP and PAI-1(r=0.615, p<0.000=, between the levels of hsCRP and FPG (r_s=0,342, P<0.000=, and between the levels of PAI-1 and FPG (r_s=0.380, p<0.000=. Conclusion: Imflammatory factors hsCRP and PAI-1 in patients of unstable angina pectoris with 2 type diabetes mellitus are higher than those who are only coronary or only 2 diabetes mellitus. The elevated-levels of hsCRPand PAI-1 have potentially predict the function to unstale plaque ruptured,thrombosis and acute heart events, they may be the reasons why there are worse prognosis in patients of unstable angina pectoris with 2 type diabetes mellitus.