Expression And Clinical Significance Of Five Multidrug Resistance Genes In Common Malignant Tumors

Objective:To investigate the expression of five multidrug resistance genes in hepatocellular cancer, lung cancer, gastric carcinoma, colorectal cancer, ovarian cancer and breast cancer tissue and explore their clinical significance.Methods: The expressions of P-gp, MRP1, LRP, GST-π, Topo-II in 120 cases of the malignant tumors were examined by immunohistochemistry stain.Results: 1.The positive rate of P-gp, MRP1, LRP, GST-πin cancers were relatively high, while the expression of Topo-II was relatively low. 2. P-gp, MRP1, LRP, GST-π, Topo-II were all relatively high expressed in hepatocellular cancer. 3. The coexpression rate of two and more genes was 95.83%,the coexpression rate of five genes was 21.67%,it is significantly higher than the mono-expression rate( p﹤0.05). 4. The expression of LRP in colorectal cancer was related to the location of tumor, which was expressed significantly higher in rectal cancer than that in colon carcinoma( p﹤0.05). The expression of MRP1 in breast cancer was related to lymphatic metastasis, the expression rate of which was evidently higher in breast cancer with lymphatic metastasis than non-lymphatic metastasis( p﹤0.05). The rest expressions of P-gp, MRP1, LRP, GST-π, Topo-II in hepatocellular cancer, lung cancer, gastric carcinoma, colorectal cancer, ovarian cancer and breast cancer were not associated with differentiation degree, preoperative chemotherapy, infiltrate depth and lymphatic metastasis(all p>0.05).Conclusions: P-gp, MRP1, LRP, GST-π, Topo-II are associated with multidrug resistance,which can be regarded as valuable indicators for clinical prognosis assessment and the decision of chemotherapeutic program. Objective: To investigate the expression of five multidrug resistance genes in hepatocellular cancer and hepatoblastoma and explore the differences of the adult and the children tumors.Methods: The expressions of P-gp, MRP1, LRP, GST-π, Topo-II in hepatocellular cancer and hepatoblastoma were examined by immuno- histochemistry stain.Results: 1.In general the positive rate of P-gp, MRP1, LRP, Topo-II in hepatoblastoma was relatively lower than that in hepatocellular cancer. 2. The expression of GST-πin hepatoblastoma was significantly higher than that in hepatocellular cancer. 3. The expression of P-gp in hepatocellular cancer was related to AFP ( p﹤0.05).The expression of P-gp and LRP in hepatoblastoma was related to AFP ( p﹤0.05).Conclusions: 1.AFP can be regarded as a valuable indicator for the expression of P-gp in hepatocellular cancer and hepatoblastoma . 2. Except for GST-π, the expression of drug resistance genes in the children tumors is relatively lower than that in the adult tumors.