The Association Between Prior Infection With Chlamydia Pneumoniae And Cerebral Infarction

Objective To studay the association between prior infection with chlamydia pneumoniae and Cerebral infarction.Methods Chlamydia pneumoniae-specfic IgG were measured in 47 patients with cerebral infarction and 48 controls with other diseases by enzyme linked immunosorbent assay test and serum concentration of total cholesterol, triglyceride, HDL-c, LDL-c and LP(a). Polymerase chain reaction (pcr) was used to demonstrate the presence of Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear(PBMC) of all the patients and controls, all the subjects were consecutive in-patients in Dongfeng Hospital, Yunyang Medical College. Diabetes mellitus and hypertension were defined on the basis of previous treatment for diabetes mellitus and hypertension .Results The positive rate of specific IgG antibody was 78.7% in patients with the cerebral infarction group and 37.5% in the control group. The positive rate of specific IgG antibody in patients with the cerebral infarction group was significantly higher than that in controls. Chlamydia pneumoniae seropositive, as adjusted by multiple logistic regression analysis using various known risk factors, was a significant independent contributing factor for cerebral infarction. The positive rate of Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear was 0.Conclusion There may exist an association between chronic chlamydia pneumoniae infection and Cerebral infarction. The method of measuring Chlamydia pneumoniae-specfic IgG by enzyme linked immunosorbent assay test is sensitive and can diagnose chronic chlamydia pneumoniae infection. But the method of measuring Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear by PCR can not diagnose chronic chlamydia pneumoniae infection.